Search results for "Biomedical and Dental Materials"

showing 3 items of 3 documents

Long-Term in vivo Evaluation of Orthotypical and Heterotypical Bioengineered Human Corneas.

2020

Purpose: Human cornea substitutes generated by tissue engineering currently require limbal stem cells for the generation of orthotypical epithelial cell cultures. We recently reported that bioengineered corneas can be fabricated in vitro from a heterotypical source obtained from Wharton’s jelly in the human umbilical cord (HWJSC). Methods: Here, we generated a partial thickness cornea model based on plastic compression nanostructured fibrin-agarose biomaterials with cornea epithelial cells on top, as an orthotypical model (HOC), or with HWJSC, as a heterotypical model (HHC), and determined their potential in vivo usefulness by implantation in an animal model. Results: No major side effects …

0301 basic medicinePathology02 engineering and technology:Chemicals and Drugs::Carbohydrates::Polysaccharides::Sepharose [Medical Subject Headings]Umbilical cord:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]heterotypical human corneaTissue engineering:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Lagomorpha::Rabbits [Medical Subject Headings]Cornea:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Optical Imaging::Tomography Optical::Tomography Optical Coherence [Medical Subject Headings]:Organisms::Eukaryota::Animals [Medical Subject Headings]:Technology and Food and Beverages::Technology Industry and Agriculture::Manufactured Materials::Biomedical and Dental Materials::Biocompatible Materials [Medical Subject Headings]Slit lamp021001 nanoscience & nanotechnologymedicine.anatomical_structure:Anatomy::Sense Organs::Eye::Anterior Eye Segment::Cornea [Medical Subject Headings]tissue engineeringStem cell0210 nano-technologyBiotechnology:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Blood Proteins::Fibrin [Medical Subject Headings]medicine.medical_specialtyHistologyStromal celllcsh:BiotechnologyBiomedical EngineeringCélulas madre mesenquimatosasBioengineering:Anatomy::Embryonic Structures::Fetus::Umbilical Cord [Medical Subject Headings]:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models Animal [Medical Subject Headings]03 medical and health sciencesIn vivolcsh:TP248.13-248.65medicine:Anatomy::Cells::Connective Tissue Cells::Stromal Cells::Mesenchymal Stromal Cells [Medical Subject Headings]:Technology and Food and Beverages::Technology Industry and Agriculture::Engineering::Bioengineering::Cell Engineering::Tissue Engineering [Medical Subject Headings]Wharton’s jelly stem cellsbioengineered corneabusiness.industryTissue engineringeye diseasesEpitheliumCórnea:Anatomy::Cells::Epithelial Cells [Medical Subject Headings]:Anatomy::Tissues::Connective Tissue::Wharton Jelly [Medical Subject Headings]030104 developmental biologyIngeniería de tejidossense organsbusinessartificial cornea
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Dental stem cell signaling pathway activation in response to hydraulic calcium silicate-based endodontic cements: A systematic review of in vitro stu…

2020

Abstract Objective To present a qualitative synthesis of in vitro studies which analyzed human dental stem cell (DSC) molecular signaling pathway activation in response to hydraulic calcium silicate-based cements (HCSCs). Methods A systematic electronic search was performed in Medline, Scopus, Embase, Web of Science and SciELO databases on January 20 and last updated on March 20, 2020. In vitro studies assessing the implication of signaling pathways in activity related marker (gene/protein) expression and mineralization induced by HCSCs in contact with human DSCs were included. Results The search identified 277 preliminary results. After discarding duplicates, and screening of titles, abstr…

MAPK/ERK pathwayMaterials scienceCellDental CementsBiocompatible Materials02 engineering and technologySMADBiological FactorsDental Materials03 medical and health sciences0302 clinical medicineCa2+/calmodulin-dependent protein kinaseMedicine and Health SciencesmedicineHumansdental stem cellsGeneral Materials ScienceGeneral DentistryBiomedical and Dental MaterialsFOS: Clinical medicineSilicatesStem CellsIn vitro toxicologyWnt signaling pathwayEndodontics and Endodontologycalcium silicate-based cementsin vitroOxides030206 dentistryCalcium Compoundsbiomineralization021001 nanoscience & nanotechnologysignaling pathwaysChemicals and DrugsCell biologyDrug Combinationsmedicine.anatomical_structurebioactivityMechanics of MaterialsDentistryStem cellSignal transduction0210 nano-technologySignal TransductionDental Materials
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Jaw osteonecrosis management around a dental implant inserted 2 years before starting treatment with zoledronic acid

2015

Journal Article; Bisphosphonates (BP) are a type of drug known to inhibit bone resorption through complex interventions. Their primary mechanism of action is aimed at the cellular level, inhibiting osteoclast activity and so bone resorption. BPs are widely used, with many patients receiving continuous treatment for years. But it is well known that these drugs can produce osteonecrosis of the jaw (ONJ). Zoledronic acid (ZA) is an intravenous BP used in the treatment and prophylaxis of bone disease in patients with malignant tumors with bone implication. ZA is the most potent BP in clinical development. This report describes the case of a 62-year-old woman with breast cancer antecedents which…

Peri-implantitisBone diseasemedicine.medical_treatmentDifosfonatosDentistryCase Report:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Peri-implantitisDental implant:Chemicals and Drugs::Organic Chemicals::Organophosphorus Compounds::Diphosphonates [Medical Subject Headings]Implantes dentales:Anatomy::Cells::Connective Tissue Cells::Macrophages::Osteoclasts [Medical Subject Headings]ImidazolesOsteonecrosisBisphosphonates:Diseases::Neoplasms [Medical Subject Headings]:CIENCIAS MÉDICAS [UNESCO]Ciencias de la saludNeoplasiasHumanosmedicine.anatomical_structureNeoplasias de la mama:Chemicals and Drugs::Biomedical and Dental Materials::Dental Materials::Dental Implants [Medical Subject Headings]UNESCO::CIENCIAS MÉDICASMaxillectomy:Diseases::Stomatognathic Diseases::Mouth Diseases::Peri-Implantitis [Medical Subject Headings]Oral SurgeryResorción óseamedicine.drugmedicine.medical_specialtyOdontología:Diseases::Musculoskeletal Diseases::Bone Diseases::Osteonecrosis [Medical Subject Headings]Bone resorptionBreast cancerOsteoclast:Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds 1-Ring::Azoles::Imidazoles [Medical Subject Headings]medicinePeriimplantitisGeneral DentistryZoledronic acid:Diseases::Neoplasms::Neoplasms by Site::Breast Neoplasms [Medical Subject Headings]Osteonecrosis of the jawbusiness.industry:Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Bone Remodeling::Bone Resorption [Medical Subject Headings]Osteoclastosmedicine.diseaseSurgeryZoledronic acid:Check Tags::Female [Medical Subject Headings]Osteonecrosis of the jawbusinessJournal of Clinical and Experimental Dentistry
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